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The effects of FGF23 are exerted primarily within the kidney where its actions result in increased phosphate excretion (decreased phosphate reabsorption) and suppression of calcitriol synthesis via inhibition of the expression of the CYP27B1 gene that encodes the PTH-inducible 1--hydroxylase enzyme
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Funding This research was funded by the National Key Research and Development Programs of China, grant number 2022YFC2603801, the Maternal and Child Health Project of Jiangsu Province (F201717), the Doctor Project of Affiliated Hospital of Jiangsu University (jdfyrc2019003), and Clinical and Virology Study of 2019-ncov Infection in Patients with Moderate to Severe Psoriasis (Jdfyxgzx005). Publishers note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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